Rimcazole dihydrochloride ( —— )

产品货号. M33914 CAS No. 75859-03-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Rimcazole dihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Rimcazole (BW 234U) dihydrochloride 是一种咔唑衍生物，部分用作 σ 受体拮抗剂。Rimcazole dihydrochloride 以中等亲和力结合多巴胺转运蛋白并抑制多巴胺摄取。Rimcazole dihydrochloride 可以减弱运动活动和致敏作用。Rimcazole dihydrochloride 也可用于癌症的研究。
产品描述

Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.
体外实验

Western Blot AnalysisCell Line:HCT-116p53+/+ cells Concentration:50 μM Incubation Time:1, 2, 3, 5, 6, 24 hours Result:Accumulation of HIF-1α protein, maximal at 6?h.No change in p53 protein levels.HIF-1α protein levels returned to normal steady-state levels within 24?h.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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CAS Number

75859-03-9
分子量

357.92
分子式

C21H28ClN3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (31.70 mM; 超声助溶 (<60°C) H2O 中的溶解度 : < 0.1 mg/mL (insoluble)
SMILES

Cl.Cl.C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1
化学全称

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1. Gilmore DL, et, al. Review of the pharmacological and clinical profile of rimcazole. CNS Drug Rev. Spring 2004;10(1):1-22.?

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产品手册

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